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Tonic repression of collagen I by the bradykinin receptor 2 in skin fibroblasts.
Wong HH, Seet SH, Bascom CC, Isfort RJ, Bard FA. Wong HH, et al. Matrix Biol. 2023 Apr;118:110-128. doi: 10.1016/j.matbio.2023.03.004. Epub 2023 Mar 15. Matrix Biol. 2023. PMID: 36924903 Free article.
This function is independent of the natural ligand, bradykinin, and of SMAD2/3 factors, instead requiring constant ERK1/2 repression. TGFbeta stimulation induces rapid BDKRB2 transcriptional downregulation. Human fibrotic fibroblasts have reduced BDKRB2 levels and e …
This function is independent of the natural ligand, bradykinin, and of SMAD2/3 factors, instead requiring constant ERK1/2 repression. TGFbet …
Improvement of skin wound healing in diabetic mice by kinin B2 receptor blockade.
Desposito D, Chollet C, Taveau C, Descamps V, Alhenc-Gelas F, Roussel R, Bouby N, Waeckel L. Desposito D, et al. Clin Sci (Lond). 2016 Jan;130(1):45-56. doi: 10.1042/CS20150295. Epub 2015 Oct 6. Clin Sci (Lond). 2016. PMID: 26443866
Impaired skin wound healing is a major medical problem in diabetic subjects. ...Levels of Bdkrb1 (encoding B1R) and Bdkrb2 (encoding B2R) mRNAs increased 1-2-fold in healthy and wounded diabetic skin compared with in non-diabetic skin. ...
Impaired skin wound healing is a major medical problem in diabetic subjects. ...Levels of Bdkrb1 (encoding B1R) and Bdkrb2 (en …
Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches.
Ali HA, Lomholt AF, Mahmoudpour SH, Hermanrud T, Bygum A, von Buchwald C, Jakobsen MA, Rasmussen ER. Ali HA, et al. PLoS One. 2019 Nov 11;14(11):e0224858. doi: 10.1371/journal.pone.0224858. eCollection 2019. PLoS One. 2019. PMID: 31710633 Free PMC article.
A well-known adverse drug reaction to ACE inhibitors is ACE inhibitor-induced angioedema (ACEi-AE). Angioedema is a swelling of skin and mucosa, which can be fatal if the airway is compromised. ...The inferior quality of some studies was due to poor organization, lack of a …
A well-known adverse drug reaction to ACE inhibitors is ACE inhibitor-induced angioedema (ACEi-AE). Angioedema is a swelling of skin …
Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways.
Arredondo-Mendoza GI, Jiménez-Salas Z, Garza FJG, Solís-Pérez E, López-Cabanillas-Lomelí M, González-Martínez BE, Campos-Góngora E. Arredondo-Mendoza GI, et al. Molecules. 2020 Aug 26;25(17):3875. doi: 10.3390/molecules25173875. Molecules. 2020. PMID: 32858788 Free PMC article.
Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, light-headedness or hyperkalemia) to specific drug molecular structure (skin rash, neutropenia and …
Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action ( …
Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas.
Kagimoto Y, Yamasaki K, Shimada-Ohmori R, Nan L, Numata Y, Aiba S. Kagimoto Y, et al. J Dermatol. 2017 Jun;44(6):690-694. doi: 10.1111/1346-8138.13726. Epub 2016 Dec 27. J Dermatol. 2017. PMID: 28026039
We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. ...
We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. …